TABLE 2.

Area Under the Receiver Operating Curves for Fluid Resuscitation, Critical Care Admission, and Two Bacterial and Viral Infection Phenotyping Subgroups

Biomarker/Clinical Score (Threshold)	Critical Care Admission Within 48 hr (95% CI)	Fluid Resuscitation (95% CI)	Definite and Probable Bacterial vs Definite and Probable Viral Infection (95% CI)	Definite Bacterial vs Definite Viral Infection (95% CI)
Alder Hey PEWS (≥ 3)	0.88 (0.84–0.92)	0.65 (0.60–0.69)	0.54 (0.50–0.58)	0.35 (0.27–0.43)
National PEWS (≥ 6)	0.83 (0.78–0.89)	0.67 (0.62–0.71)	0.50 (0.46–0.55)	0.40 (0.32–0.49)
MR-proADM (≥ 0.70 nmol/L)	0.62 (0.51–0.73)	0.72 (0.67–0.78)	0.63 (0.58–0.67)	0.63 (0.53–0.73)
Procalcitonin (≥ 0.50 ng/mL)	0.57 (0.46–0.68)	0.67 (0.62–0.72)	0.78 (0.74–0.82)	0.77 (0.69–0.84)
C-reactive protein (≥ 20 mg/dL)	0.58 (0.50–0.66)	0.57 (0.52–0.63)	NA	NA
National PEWS (≥ 6) and procalcitonin (≥ 0.50 ng/mL)	0.84 (0.78–0.90)	0.71 (0.66–0.75)	0.77 (0.74–0.81)	0.83 (0.77–0.89)
National PEWS (≥ 6) and MR-proADM (≥ 0.70 nmol/L)	0.85 (0.78–0.92)	0.73 (0.68–0.79)	0.64 (0.59–0.68)	0.71 (0.63–0.80)
National PEWS (≥ 6) and procalcitonin (≥ 0.50 ng/mL) and MR-proADM (≥ 0.70 nmol/L)	0.85 (0.78–0.92)	0.74 (0.68–0.79)	0.73 (0.68–0.77)	0.83 (0.76–0.90)

MR-proADM = mid-regional pro-adrenomedullin, NA = not available, PEWS = Pediatric Early Warning Score.