TABLE 2.
Hemostasis Protein Levels in Invasive Bacterial Infections: Stratified by Pathogen Group
| Hemostasis Protein | Group A streptococcus, n = 44 Median (IQR) | Neisseria meningitides, n = 83 Median (IQR) | Streptococcus pneumoniae, n = 64 Median (IQR) | Staphylococcus aureus, n = 50 Median (IQR) | p a |
|---|---|---|---|---|---|
| Serum | |||||
| Fibronectin (µg/mL) | 22 (6–61) | 43 (14–91) | 67 (20–123) | 51 (21–150) | 0.03 |
| Plasminogen activator inhibitor type 1 (ng/mL) | 87 (58–159) | 83 (24–208) | 130 (56–198) | 87 (12–186) | 0.52 |
| Thrombomodulin (pg/mL) | 409 (10–1,559) | 847 (10 – 2,861) | 10 (10–918) | 10 (10–703) | < 0.001 |
| ADAMTS-13 (ng/mL) | 9 (2–60) | 33 (7–87) | 19 (5–45) | 12 (2–45) | 0.13 |
| Citrate plasma | n = 20 | n = 43 | n = 34 | n = 25 | |
| Factor XI (%) | 53 (25–289) | 50 (35–95) | 110 (53–300) | 55 (35–300) | 0.11 |
| Protein C (%) | 40 (23–81) | 40 (25–50) | 55 (40–79) | 35 (25–65) | 0.11 |
| Protein S (%) | 65 (46–136) | 95 (65–148) | 155 (85–315) | 95 (75–240) | 0.14 |
| von Willebrand factor (%) | 300 (103–300) | 300 (183–300) | 300 (103–300) | 300 (300–300) | 0.38 |
ADAMTS-13 = a disintegrin and metalloprotease with thrombospondin type-1 motif, member 13, IQR = interquartile range.
a
p values adjusted for multiple testing.