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. 2022 Nov 29;45(3):315–327. doi: 10.1007/s00281-022-00971-3

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Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Overview of age-associated B cells (ABCs), including a schematic of development within the spleen: (1) follicular B cells (FOB; also include MZ populations) receive signals from Th1-type cytokines or other nearby interactions, and (2) uptake either endogenous double-stranded (DS)DNA or RNA-associated antigen. (3) These antigens activate toll-like receptor (TLR) 9 and TLR7 and following several divisions and expression of T-bet become an ABC. ABCs can be found in several lymphoid organs, the meninges, and brain parenchyma