Table 6.
Anti-inflammatory effect of the solvent fractions of A. mexicana fruits on cotton pellet-induced granuloma in rats.
| Treatment group | BV (ml) | Change in paw volume (mean ± S.E.M) (ml) (percent inhibition (%)) | |||
|---|---|---|---|---|---|
| 1 hour | 2 hours | 3 hours | 4 hours | ||
| 2% tween | 0.22 ± 0.1 | 0.43 ± 0.02 | 0.44 ± 0.03 | 0.42 ± 0.03 | 0.40 ± 0.03 |
| Aspirin, 200 mg/kg | 0.21 ± 0.1 | 0.28 ± 0.04∗abcd (30.89) | 0.25 ± 0.04∗abcde (41.44) | 0.21 ± 0.03∗abcde (50) | 0.17 ± 0.02#abcd (56) |
| 100 mg/kg AF | 0.20 ± 0.01 | 0.39 ± 0.04 (3.85) | 0.38 ± 0.04 (14.67) | 0.36 ± 0.03 (14.92) | 0.35 ± 0.03 (22.50) |
| 200 mg/kg AF | 0.20 ± 0.01 | 0.37 ± 0.01 (8.55) | 0.34 ± 0.01∗a (27.41) | 0.31 ± 0.1∗a (37.09) | 0.27 ± 0.03∗a (45) |
| 400 mg/kg AF | 0.21 ± 0.01 | 0.32 ± 0.01∗ab (20.94) | .30 ± 0.03∗ab (29.34) | 0.28 ± 0.03∗ab (42.34) | 0.23 ± 0.01∗ab (45.83) |
| 100 mg/kg n-HF | 0.22 ± 0.01 | 0.36 ± 0.05∗a (13.01) | 0.36 ± 0.06∗a (17.87) | 0.33 ± 0.06∗a (26.63) | 0.28 ± 0.02∗ab (31.54) |
| 200 mg/kg n-HF | 0.22 ± 0.01 | 0.34 ± 0.05∗a (16.26) | 0.35 ± 0.03∗a (21.29) | 0.30 ± 0.01∗a (28.57) | 0.26 ± 0.01∗ab (35.27) |
| 400 mg/kg n-HF | 0.21 ± 0.02 | 0.29 ± 0.02∗abc (28.05) | 0.28 ± 0.02∗abe (37.26) | 0.29 ± 0.10∗abc (43) | 0.22 ± 0.01∗ab (44.81) |
| 100 mg/kg EAF | 0.22 ± 0.01 | 0.34 ± 0.04∗a (18.29) | 0.32 ± 0.03∗a (27.37) | 0.28 ± 0.03∗a (33.33) | 0.26 ± 0.02∗ab (34.85) |
| 200 mg/kg EAF | 0.21 ± 0.01 | 0.29 ± 0.04∗abc (27.64) | 0.26 ± 0.05∗abcde (41.01) | 0.22 ± 0.05∗abcd (47.62) | 0.18 ± 0.06∗abc (54.36) |
| 400 mg/kg EAF | 0.21 ± 0.01 | 0.26 ± 0.02∗abcde (35.77) | 0.22 ± 0.01∗abcde (48.29) | 0.19 ± 0.01∗abcde (53.96) | 0.15 ± 0.01∗abcd (61.41) |
Values are expressed as mean ± SEM (n = 6 rats in each group) and analyzed by one-way ANOVA followed by post hoc Tuckey's test; acompared with 2% tween 80, bcompared with 100 mg/kg AF, ccompared with 200 mg/kg AF; dcompared with 100 mg/kg n-HF;e100 mg/kg EAF; ∗=p < 0.01; BV = basal volume; Dexa = dexamethasone; 2% tween 80 = negative control; AF, n-HF, and EAF are aqueous, n-hexane, and ethyl acetate fractions of A. mexicana, respectively.