TABLE 2.
Population blood work parameters
| GDH group (n = 29) | Control group (n = 594) | |||||||
|---|---|---|---|---|---|---|---|---|
| Characteristics | Reference range | Median (range) | No. (%) below reference range | No. (%) above reference range | Median (range) | No. (%) below reference range | No. (%) above reference range | Adjusted P‐value |
| Hematologic parameters | ||||||||
| Hematocrit (%) | 40‐55 | 40 (27‐53) | 12 (41.4%) | 0 (0.0%) | 46 (6‐76) | 121 (20.4%) | 36 (6 1%) | .02 |
| Hemoglobin (gm/dL) | 14‐19 | 13 (9.4‐19) | 17 (58.6%) | 0 (0.0%) | 16 (1.7‐25) | 162 (27.3%) | 33 (5.6%) | .05 |
| MCV (fL) | 65‐75 | 68 (54‐77) | 4 (13.8%) | 1 (3.4%) | 69 (52‐95) | 65 (10.9%) | 29 (4.9%) | 1 |
| White blood cells (/μL) | 6 000‐13 000 | 11 800 (4 900‐28 000) | 2 (6.9%) | 10 (34.5%) | 9 850 (700‐65 200) | 65 (10.9%) | 170 (28.6%) | .9 |
| Neutrophils (/μL) | 3 000‐10 500 | 10 390 (2 000‐23 200) | 1 (3.4%) | 7 (24.1%) | 6 800 (0‐6,000) | 22 (3.7%) | 143 (24.1%) | 1 |
| Lymphocytes (/μL) | 1 000‐4 000 | 4113 (1 000‐7 500) | 0 (0.0%) | 7 (24.1%) | 1 600 (100‐7 700) | 109 (18.4%) | 21 (3.5%) | .003 |
| Neutrophil/lymphocyte ratio | 2.3 (0.9‐12) | 4.7 (0‐122) | .003 | |||||
| Monocytes (/μL) | 150‐1200 | 857 (100‐1 400) | 1 (3.4%) | 3 (10.3%) | 500 (0‐5 200) | 10 (1.7%) | 85 (14.3%) | 1 |
| Eosinophils (/μL) | 0‐1500 | 1247 (0‐6 296) | 3 (10.3%) | 300 (0‐15 500) | 19 (3.2%) | .003 | ||
| Platelets (/μL) | 150 000‐400 000 | 322 000 (132 000‐497 000) | 1 (3.4%) | 4 (13.8%) | 262 000 (3 000‐822 000) | 69 (11.6%) | 82 (13.8%) | 1 |
| Biochemical parameters | ||||||||
| Sodium (mmol/L) | 143‐151 | 147 (143‐155) | 3 (10.3%) | 146 (143‐162) | 32 (5.4%) | 1 | ||
| Potassium (mmol/L) | 3.6‐4.8 | 4.4 (3.3‐4.8) | 4 (13.8%) | 4.2 (2.6‐4.8) | 33 (5.6%) | 1 | ||
| Chloride (mmol/L) | 108‐116 | 114 (106‐136) | 1 (3.4%) | 10 (34.5%) | 111 (91‐139) | 88 (14.8%) | 43 (7.2%) | .003 |
| Bicarbonate (mmol/L) | 20‐29 | 20 (13‐25) | 12 (41.4%) | 0 (0.0%) | 21 (8‐34) | 182 (30.6%) | 3 (0.5%) | 1 |
| Phosphorus (mg/dL) | 2.6‐5.2 | 4.2 (1.7‐7.1) | 2 (6.9%) | 5 (17.2%) | 3.9 (0.8‐28) | 48 (8.1%) | 84 (14.1%) | 1 |
| Calcium (mg/dL) | 9.6‐11.2 | 10 (8.2‐12) | 7 (24.1%) | 2 (6.9%) | 10 (4‐18) | 143 (24.1%) | 53 (8.9%) | 1 |
| BUN (mg/dL) | 11‐33 | 17 (6‐47) | 5 (17.2%) | 3 (10.3%) | 15 (3‐270) | 147 (24.7%) | 49 (8.2%) | 1 |
| Creatinine (mg/dL) | 0.8‐1.5 | 1.1 (0.6‐2.1) | 3 (10.3%) | 3 (10.3%) | 0.9 (0.1‐16) | 208 (35%) | 57 (9.6%) | .003 |
| Bilirubin (mg/dL) | 0.0‐0.2 | 0.2 (0.1‐0.4) | 3 (10.3%) | 0.2 (0‐23) | 61 (10.3%) | 1 | ||
| Glucose (mg/dL) | 86‐118 | 84 (36‐401) | 16 (55.2%) | 2 (6.9%) | 97 (7‐307) | 127 (21.4%) | 53 (8.9%) | .003 |
| Albumin (g/dL) | 3.4‐4.3 | 2.4 (1.3‐3.4) | 28 (96.6%) | 0 (0.0%) | 3.4 (0.7‐5) | 253 (42.6%) | 16 (2.7%) | .003 |
| Globulin (g/dL) | 2.9 (1.6‐4.4) | 1 (3.4%) | 11 (37.9%) | 2.4 (0.7‐6.4) | 39 (6.6%) | 82 (13.8%) | .003 | |
| Albumin/globulin ratio | 0.7 (0.4‐1.6) | 1.4 (0.3‐3) | .003 | |||||
| ALT (IU/L) | 21‐72 | 52 (18‐195) | 1 (3.4%) | 8 (27.6%) | 45 (2‐3 923) | 50 (8.4%) | 168 (28.3%) | 1 |
| AST (IU/L) | 20‐49 | 66 (27‐240) | 0 (0.0%) | 18 (62.1%) | 34 (13‐13 312) | 30 (5.1%) | 154 (25.9%) | .003 |
| ALP (IU/L) | 14‐91 | 41 (14‐2184) | 0 (0.0%) | 3 (10.3%) | 58 (7‐4 282) | 17 (2.9%) | 196 (33%) | .2 |
| GGT (IU/L) | 0‐5 | 3 (0‐7) | 2 (6.9%) | 3 (0‐113) | 103 (17.3%) | 1 | ||
| Cholesterol (mg/dL) | 139‐353 | 100 (45‐230) | 24 (82.8%) | 0 (0.0%) | 190 (45‐978) | 132 (22.2%) | 23 (3.9%) | .003 |
| Cobalamin (ng/L) a | 271‐875 | 423 (184‐927) | 2 (18.2%) | 1 (9.1%) | 410 (150‐2 965) | 93 (28.3%) | 29 (8.8%) | 1 |
a
Sample size for cobalamin measurements are n = 11 GDH dogs and n = 329 control dogs.
Bolded P‐values correspond with statiscitally significant findings.