TABLE 3.
Performance of clinicopathologic data for detection of GDH
| Clinicopathologic parameter | Optimal cut point | Sensitivity % (95% CI) | Specificity % (95% CI) | AUC (95% CI) |
|---|---|---|---|---|
| Resting cortisol (μg/dL) | <0.85 | 96.2 (81.2‐99.8) | 98.2 (96.8‐99.0) | 0.988 (0.978‐0.999) |
| Albumin (g/dL) | <2.950 | 89.7 (73.6‐96.4) | 77.4 (73.9‐80.6) | 0.882 (0.839‐0.925) |
| Albumin/globulin ratio | <1.081 | 86.2 (69.4‐94.5) | 78.8 (75.3‐81.9) | 0.886 (0.827‐0.944) |
| AST (IU/L) | >44.50 | 79.3 (61.6‐90.1) | 70.7 (66.9‐74.2) | 0.772 (0.703‐0.840) |
| Chloride (mmol/L) | >111.5 | 86.2 (69 4‐94.5) | 53.5 (49.5‐57.4) | 0.749 (0.660‐0.837) |
| Cholesterol (mg/dL) | <133.5 | 82.8 (65.5‐92.4) | 81.3 (78.0‐84.2) | 0.878 (0.814‐0.942) |
| Cobalamin (ng/L) | >318.5 | 81.8 (52.3‐96.8) | 35.3 (30.3‐40.6) | 0.531 (0.378‐0.681) |
| Creatinine (mg/dL) | >0.95 | 82.8 (65.5‐92.4) | 60.6 (56.6‐64.5) | 0.718 (0.639‐0.797) |
| Eosinophils (/μL) | >403.5 | 72.4 (54.3‐85.3) | 67.3 (63.5‐71.0) | 0.734 (0.643‐0.825) |
| Globulin (g/dL) | >2.450 | 82.8 (65.5‐92.4) | 55.6 (51.5‐59.5) | 0.723 (0.631‐0.815) |
| Glucose (mg/dL) | <89.50 | 69.0 (50.5‐82.7) | 70.9 (67.1‐74.4) | 0.705 (0.597‐0.812) |
| Hematocrit (%) | <42.60 | 69.0 (50.8‐82.7) | 68.0 (64.2‐71.6) | 0.683 (0.587‐0.778) |
| Hemoglobin (g/dL) | <14.15 | 62.1 (44.0‐77.3) | 70.2 (66.4‐73.7) | 0.674 (0.575‐0.773) |
| Neutrophil/lymphocyte ratio | <2.659 | 65.5 (47.4‐80.1) | 81.4 (78.1‐84.3) | 0.755 (0.660‐0.850) |
| Lymphocyte (/μL) | >1750 | 96.6 (82.8‐99.8) | 60.3 (56.3‐64.1) | 0.828 (0.762‐0.894) |