Figure 3.

The differential functions between epithelial cells across sub-clusters and samples. (A) The UMAP plot shows four epithelial cells clusters. (B) The barplot shows the percentages of the different epithelial cell clusters between the two samples. (C) The inferred CNV based on epithelial cell scRNA-seq divided by clusters. Red indicates amplification and blue indicates deletion. (D-F) GSVA analysis based on Hallmark datasets. (D) The different pathways between the four epithelial cell clusters. Different pathways between primary and metastatic epithelial cell 1 (E) and epithelial cell 2 (F). UMAP, uniform manifold approximation and projection; CNV, copy number variation; scRNA-seq, single-cell RNA sequencing; GSVA, gene set variation analysis.