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. 2022 Nov 30;22:919. doi: 10.1186/s12877-022-03477-7

Table 2.

Protective and risk factors for frailty progression and reversibility

Risk factors associated with frailty progression Protective factors associated with frailty reversal
Socio-demographic factors
 Older age  + 
 Younger age  + 
 Low aging satisfaction  + 
 Older subjective age  + 
 Female sex  + 
 Higher education  + 
 Employment  + 
Anthropometric variables and lifestyles
 Smoking pack years  + 
 Waist to hip ratio  + 
 Combined exercise-nutrition intervention  + 
HIV related variables
 Duration of ART exposure  + 
 HIV virologic suppression  + 
 CD4 nadir > 500  + 
 Absence of AIDS diagnosis  + 
 Cumulative exposure to zalcitabine (ddC)  + 
 HIV duration > 20 years  +