Table 1.

Effect sizes for the relationship between pro-inflammatory markers and cognitive dysfunctioning.

Test	k	N	r	95% CI	z	p	Q test	P value (Q test)	I2
All psychotic and mood disorders
Global cognitive performance	53	27,908	−0.076	−0.126 to −0.027	−3.011	0.003*	230.141	<0.001	77.4
Verbal memory	36	3501	−0.089	−0.148 to −0.029	−2.900	0.004*	128.63	<0.001	72.79
Visual memory	15	24,174	−0.036	−0.049 to −0.023	−5.533	<0.001*	29.17	0.010	52.01
Working memory	23	1902	−0.065	−0.118 to −0.011	−2.363	0.018*	37.95	0.019	42.03
Attention	27	26,243	−0.027	−0.091 to 0.037	−0.820	0.412	160.69	<0.001	83.82
Processing speed	20	2149	−0.082	−0.151 to −0.012	−2.295	0.022*	47.46	<0.001	59.96
Reasoning	37	3284	−0.025	−0.096 to 0.045	−0.882	0.378	80.18	<0.001	55.10
Language	21	2419	−0.052	−0.144 to 0.041	−1.100	0.271	85.56	<0.001	76.62
Schizophrenia
Global cognitive performance	27	2609	−0.036	−0.113 to 0.042	−0.897	0.370	87.82	<0.001	70.39
Verbal memory	22	2156	−0.072	−0.172 to 0.030	−1.377	0.168	99.34	<0.001	78.86
Visual memory	9	745	−0.142	−0.241 to −0.040	−2.724	0.006*	12.93	0.114	38.13
Working memory	16	1267	0.002	−0.071 to 0.076	0.066	0.947	22.66	0.092	33.79
Attention	16	2011	−0.071	−0.164 to 0.022	−1.496	0.135	49.65	<0.001	69.79
Processing speed	12	1314	−0.080	−0.171 to 0.013	−1.695	0.090	25.11	0.009	56.18
Reasoning	18	1786	−0.026	−0.096 to 0.045	−0.712	0.476	31.52	0.017	46.06
Language	16	1861	−0.033	−0.137 to 0.072	−0.616	0.538	65.62	<0.001	77.14
Bipolar disorder
Global cognitive performance	13	2012	−0.095	−0.168 to −0.020	−2.474	0.013*	21.42	0.045	43.98
Verbal memory	8	929	−0.085	−0.164 to −0.005	−2.082	0.037	9.52	0.218	26.45
Visual memory	4	839	−0.108	−0.196 to −0.019	−2.379	0.017*	4.017	0.260	25.31
Working memory	6	605	−0.153	−0.231 to −0.074	−3.744	<0.001*	4.65	0.460	0.00
Attention	5	1366	0.025	−0.105 to 0.154	0.371	0.711	11.61	0.021	65.54
Processing speed	5	591	−0.130	−0.318 to 0.067	−1.294	0.196	20.07	<0.001	80.07
Reasoning	12	1036	0.002	−0.124 to 0.128	0.033	0.974	37.42	<0.001	70.60
Language	3	458	−0.162	−0.363 to 0.053	−1.482	0.138	9.01	0.011	77.80
MDD
Global cognitive performance	13	23,245	−0.133	−0.257 to −0.006	−2.051	0.040	72.71	<0.001	83.50
Verbal memory	6	416	−0.186	−0.375 to 0.018	−1.785	0.074	19.62	0.001	74.51
Attention	6	22,866	0.003	−0.117 to 0.123	0.043	0.965	15.25	0.009	67.22
Processing speed	3	244	−0.066	−0.191 to 0.062	−1.009	0.313	0.29	0.863	0.00
Reasoning	7	462	−0.053	−0.183 to 0.079	−0.786	0.432	9.95	0.127	39.67

K number of studies, N total number of participants, r mean effect size of correlation.

*Statistically significant after Benjamini–Hochberg procedure correction.