Table 1.
A: Main baseline demographics of matched cohorts comparing BP-CCBs with amlodipine. A: patients with no prior neuropsychiatric diagnosis. B: patients with a prior neuropsychiatric diagnosisa.
| A: no prior neuropsychiatric diagnosis | B: with prior neuropsychiatric diagnosis | |||
|---|---|---|---|---|
| BP-CCB | Amlodipine | BP-CCB | Amlodipine | |
| Cohort size (n) | 44,731 | 44,731 | 17,896 | 17,896 |
| Age at index (y, SD) | 58.3 (17.5) | 58.8 (16.8) | 56.2 (17.1) | 56.0 (15.7) |
| Sex (M:F %) | 42:58 | 43:57 | 38:62 | 38:62 |
| Race (W,B,O %)b | 50,29,21 | 48,28,24 | 61,26,13 | 62,26,12 |
| Blood pressure | 136/77 | 136/77 | 134/77c | 135/79c |
| Body mass index (SD) | 30.1 (6.7) | 29.8 (6.7) | 30.7 (7.3) | 30.4 (7.1) |
| Prior psychotic disorder (%) | 0 | 0 | 3 | 3 |
| Prior affective disorder (%) | 0 | 0 | 33 | 33 |
| Prior anxiety disorder (%) | 0 | 0 | 32 | 33 |
| Prior substance use disorder (%) | 0 | 0 | 27 | 27 |
| Prior sleep disorder (%) | 0 | 0 | 33 | 34 |
| Prior delirium (%) | 0 | 0 | 4 | 4 |
| Prior dementia (%) | 0 | 0 | 2 | 3 |
| Prior movement disorder (%) | 0 | 0 | 6 | 6 |
aFor additional cohort demographics see Supplementary Table 3. For ICD-10 codes see text. In B, percentages add up to more than 100% since a patient may have a diagnosis in more than one category, and also more than one diagnosis within each category.
bW: white. B: black. O: other or not known. SD: standard deviation.
cStandard difference between cohorts for diastolic blood pressure = 0.12.