Table 2.

Multivariable Cox proportional hazards model for overall survival (OS).

No. of patients = 362* No. of deaths = 313	Hazard Ratio	95% CI	p-value
Interaction effects
pS6 status*Histology			<0.001
High vs. Low
In Epithelioid	0.87	(0.66–1.14)	0.31
In Non-epithelioid	2.12	(1.42–3.17)	<0.001
Epithelioid vs. Non-epithelioid
In High pS6	0.26	(0.18–0.38)	<0.001
In Low pS6	0.64	(0.46–0.89)	0.0075
Main effects
Gender
Female vs. Male	0.55	(0.39–0.79)	0.0011
Treatment strategy
Complete Resection vs. Palliative	0.50	(0.39–0.64)	<0.001

(*) 2 patients who haven’t received treatment are excluded.

Note1: Variables of interest initially included in the model: Gender, Ethnicity, ECOG performance status, Smoking history, Exposure to asbestos, Age at diagnosis, Histology, Localization of tumour, Clinical staging, Treatment strategy.

Note2: P-values corresponding to the non-significant variables: Age at diagnosis: 0.87; Exposure to asbestos: 0.58; Clinical staging: 0.61; Ethnicity: 0.68; Smoking history: 0.54; ECOG performance status: 0.31; Localization of tumour: 0.21.

Note3: Ethnicity: Categories African, East Asian and Other are combined; Smoking history: Categories Current and Former are combined; Exposure to asbestos: Categories Yes and Possible are combined.