Table 3.

Multivariable Cox proportional hazards model for progression-free survival (PFS).

No. of patients = 362* No. of PFS events = 338	Hazard Ratio	95% CI	p-value
Interaction effects
pS6 status*Histology			<0.001
High vs. Low
In Epithelioid	0.74	(0.57–0.97)	0.028
In Non-epithelioid	2.06	(1.39–3.07)	<0.001
Epithelioid vs. Non-epithelioid
In High ps6	0.32	(0.23–0.46)	<0.001
In Low ps6	0.89	(0.65–1.22)	0.48
Main effects
Gender
Female vs. Male	0.61	(0.43–0.85)	0.0034
Treatment strategy
Complete Resection vs. Palliative	0.55	(0.44–0.70)	<0.001

(*) 2 patients who haven’t received treatment are excluded.

Note1: Variables of interest initially included in the model: Gender, Ethnicity, ECOG performance status, Smoking history, Exposure to asbestos, Age at diagnosis, Histology, Localization of tumour, Clinical staging, Treatment strategy.

Note2: P-values corresponding to the non-significant variables: Ethnicity: 0.85; Age at diagnosis: 0.50; ECOG performance status: 0.49; Exposure to asbestos: 0.53; Clinical staging: 0.33; Smoking history: 0.36; Localization of tumour: 0.22.

Note3: Ethnicity: Categories African, East Asian and Other are combined; Smoking history: Categories Current and Former are combined; Exposure to asbestos: Categories Yes and Possible are combined.