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. 2022 Apr 22;27(8):3544–3555. doi: 10.1038/s41380-022-01549-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Individual animal data is shown alongside with the mean (black diamond) ± 95% confidence intervals to indicate statistical differences among the subgroups. Selected results of the ANOVA at group level are indicated. All descriptive statistics, model summaries, and ANOVA results are provided in Supplementary Table 1–6. Diurnal rhythmicity of corticosterone plasma levels in female (a) and male (c) Fkbp5-humanised controls or ELA-exposed mice. A different scale for males than females was used to make the pattern better visible. Significant diurnal rhythm was seen in CG-allele carrying female and male controls () and ELA-exposed mice (), as well as in AT-allele carrying control () and ELA-exposed males (). Morning corticosterone was higher in AT- vs. CG-allele carrying females (p = 0.03, $). Comparison of adrenal weights in females (b) and males (d). Female CG-allele carrying controls differ from most other subgroups (SNP × ELA × sex p = 0.04, #).

Inline graphic — Individual animal data is shown alongside with the mean (black diamond) ± 95% confidence intervals to indicate statistical differences among the subgroups. Selected results of the ANOVA at group level are indicated. All descriptive statistics, model summaries, and ANOVA results are provided in Supplementary Table 1–6. Diurnal rhythmicity of corticosterone plasma levels in female (a) and male (c) Fkbp5-humanised controls or ELA-exposed mice. A different scale for males than females was used to make the pattern better visible. Significant diurnal rhythm was seen in CG-allele carrying female and male controls () and ELA-exposed mice (), as well as in AT-allele carrying control () and ELA-exposed males (). Morning corticosterone was higher in AT- vs. CG-allele carrying females (p = 0.03, $). Comparison of adrenal weights in females (b) and males (d). Female CG-allele carrying controls differ from most other subgroups (SNP × ELA × sex p = 0.04, #).