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. 2022 Apr 22;27(8):3544–3555. doi: 10.1038/s41380-022-01549-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Expression levels [FPKM] of the glucocorticoid receptor (Nr3c1, GR), mineralocorticoid receptor (Nr3c2), Fkbp5 and heat shock protein 90 (Hsp90ab1) of individual female AT- or CG-allele carriers that experienced ELA or undisturbed maternal care (control) are visualised alongside with the mean ± 95% confidence intervals. Plots are shown separate for hypothalamus (top), ventral hippocampus (middle) and dorsal hippocampus (bottom). Descriptive statistics and an overview of the significant model terms in the ANOVA are provided in the Supplementary Tables 38 and 39. In all three regions, AT- vs. CG-allele carriers expressed less Hsp90 (hypothalamus p = 0.0006, ventral hippocampus p = 0.009, dorsal hippocampus p = 0.009). Fkbp5 was lower expressed in the hippocampi of AT- vs. CG-allele carriers (p = 0.01) and Nr3c2 was lower expressed in the ventral hippocampus of ELA-exposed vs. control mice (p = 0.03) as well as lower expressed in the dorsal hippocampus of AT- vs. CG-allele carriers (p = 0.03).