Table 3.

Enriched KEGG pathways in Fkbp5-humanised females.

Tissue	Group	Comparison	KEGG Pathway	p	Mean
Hypothalamus	Overall	AT vs. CG	Dopaminergic synapse	0.002	−0.012
			Circadian entrainment	0.003	−0.943
			ECM-receptor interaction	0.007	2.702
			Oxytocin signalling pathway	0.020	−0.115
			Long-term potentiation	0.022	−0.189
			Ras signalling pathway	0.025	−0.028
			Protein digestion & absorption	0.029	2.051
			Cholinergic synapse	0.030	−0.958
			Long-term depression	0.037	−0.893
			Calcium signalling pathway	0.041	−0.779
			cAMP signalling pathway	0.049	1.689
Ventral Hippocampus	overall	AT vs. CG	Ribosome	0.007	2.496
			Phosphatidylinositol signalling	0.012	−0.470
			Inositol phosphate metabolism	0.014	−0.418
			cAMP signalling pathway	0.024	−0.043
			Oxytocin signalling pathway	0.042	−0.804
			Aldosterone synthesis & secretion	0.043	−0.818
	Controls	AT vs. CG	Ribosome	0.014	2.252
			Oxidative phosphorylation	0.030	1.950
	ELA	AT vs. CG	Dopaminergic synapse cAMP	0.042	−0.794
			signalling pathway	0.043	−0.781
	overall	ELA vs. Con	Dopaminergic synapse	0.019	−0.218
			Circadian entrainment	0.021	−0.173
			Endocannabinoid signalling	0.032	−0.912

The DEGs detected in the dorsal hippocampus were not significantly overrepresented in individual KEGG pathways.

p = p-value of geometric mean, Mean = mean difference of fold changes, ECM = extracellular matrix, Ras = rat sarcoma, cAMP = adenosine 3’,5’-cyclic monophosphate, AT = Fkbp5 rs1360780-A/T (high induction) allele, CG = Fkbp5 rs1360780-C/G (resilience) allele.