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. 2022 Jun 15;27(9):3875–3884. doi: 10.1038/s41380-022-01624-5

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A The scatter plot describes the DNAmTL with a linear fit at AUD and HC respectively. Individuals with AUD had rapid decrease in DNAmTL comparing to HC. B The bar plots show estimated means of the Age-adjusted DNAmTL after controlling for sex, race, six blood cell counts (basic model). The DNAmTL differed significantly between AUD cases and HC (β = −0.11 kilobases per year, p = 4.0 × 10⁻¹²).