Table 1.

Association of DNAmTL with alcohol use and liver function enzyme biomarkers.

	Basic model			Full model
	β	SE	P-value	β	SE	P-value
NIAAA sample
Total drinks	−0.042	0.008	3.2 × 10−7	−0.031	0.008	0.0001
No of drinking days	−0.023	0.010	0.03	−0.010	0.010	0.34
Average drinks per day	−0.040	0.008	2.1 × 10−8	−0.030	0.008	0.0002
Heavy drinking days	−0.039	0.011	0.0002	−0.022	0.011	0.04
ADS score	−0.003	0.001	0.004	−0.002	0.001	0.023
GGT	−0.020	0.007	0.003	−0.021	0.006	0.002
ALT	−0.008	0.007	0.25	−0.006	0.007	0.36
AST	−0.019	0.007	0.005	−0.018	0.007	0.005
GS sample of unit of weekly alcohol use
Data set1 (n = 1501)	−0.0017	0.00032	2.09 × 10−7	−0.0009	0.00032	0.003
Data set2 (n = 2718)	−0.0018	0.00025	1.44 × 10−12	−0.0012	0.00025	4.64 × 10−6

AUD alcohol use disorder, GGT gamma-glutamyl transferase, ALT alanine aminotransferase, AST aspartate aminotransferase, ADS Alcohol Dependence Scale, Heavy drinking days are defined as ≥4 drinks a day for females; ≥5 drinks a day for males. Models were adjusted for age, gender, race, AUD diagnosis, six blood cell counts in the basic model, and additionally adjusted for smoking status, and body mass index in the full model, NIAAA National Institute on Alcohol Abuse and Alcoholism, GS Generation Scotland cohort.

Bold values indicate statistical significance P < 0.05.