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. 2022 Aug 31;102(12):1400–1405. doi: 10.1038/s41374-022-00829-0

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A Numbers of overlapping SNVs detected after differential processing in the three tissues. B Bar plots of the tumor mutational burdens detected in all samples. C Top 30 frequent SNVs and affected genes per tissue and sample. D, E Pairwise correlations between gene expression profiles of all combinations of processing steps for the three tissues analyzed visualized as scatter plots (D) and a correlation heatmap (E).