Table.

Multivariate log-binominal model analysis of the risk for stillbirth and early and late preterm birth according to the time point of SARS-CoV-2 infections (early vs late infection)

Parameter	Stillbirth (all patients)			Early PTB (only live births)			Late PTB (only live births)
	RR	95% CI	P value	RR	95% CI	P value	RR	95% CI	P value
Maternal age (per year increase)	0.98	0.91–1.06	.618	1.05	0.99–1.12	.096	1.01	0.99–1.04	.266
History of miscarriage or preterm delivery	4.97	1.38–17.98	.014a	1.22	0.19–7.98	.837	1.76	1.06–2.91	.027a
In-patient care for SARS-COV-2 infection	16.62	3.34–82.54	.001a	12.97	5.37–31.33	<.001a	3.99	2.77–5.77	<.001a
In-patient care for other obstetrical complications	25.49	5.82–111.60	<.001a	7.63	3.09–18.83	<.001a	5.27	3.78–7.36	<.001a
Early (1st and 2nd trimester) vs late (3rd trimester) infection	2.76	1.15–6.64	.023a	2.07	1.10–3.91	.025a	0.60	0.44–0.81	.001a

RR adjusted for maternal age, SARS-CoV-2 infection needing in-patients’ treatment, obstetrical reasons urging in-patients’ treatment and history of miscarriage or preterm delivery.

CI, confidence interval; PTB, preterm birth; RR, risk ratio.

Iannaccone. Preterm birth risk after symptomatic SARS-CoV-2 in pregnancy. Am J Obstet Gynecol 2023.

^aIndicates significant P values.