Supplemental Table.
Baseline characteristics of the study cohort
| Parameter | Number or mean | % or SD | Early infection (n=523, 45.5%) number or mean |
% or SD | Late infection (n=626, 54.5%) number or mean | % or SD |
|---|---|---|---|---|---|---|
| Maternal age (y) | 31 | ± 5 | 31.47 | ±4.879 | 31.2 | ±5.449 |
| In-patient care for SARS-COV-2 infection | 177 | 15.4% | 42 | 8% | 135 | 21.6% |
| In-patient care for obstetrical complications | 207 | 18.0% | 96 | 18.4% | 129 | 20.6% |
| Vaccinateda | 0 | 0% | — | — | ||
| History of miscarriage or preterm delivery | 24 | 2.1% | 11 | 2.1% | 13 | 2.1% |
| Timing of infection | ||||||
| Gestational age at infection (wk, all patients) | 26 | ± 9 | 18.65 (range, 1–27) | ±6.599 | 33.0 (range, 38–37 | ±2.848 |
| Gestational age at delivery (wk, all patients) | 39 | ± 3 | 39.01 | ±3187 | 38.77 | ±2.486 |
| Gestational age at delivery (wk, only live births; n=1128) | 39 | ± 3 | 39.26 | ±2.696 | 38.80 | 2.487 |
| Preterm ≤37+0 wk | 201b | 17.8% | 77 | 14.7% | 142 | 22.7% |
| Preterm early ≤32+0 wk | 37 | 3.3% | 28 | 5.4% | 18 | 2.9 |
| Preterm late 32+1 to 37+0 wk | 164 | 14.5% | 49 | 9.4% | 124 | 19.8% |
| Pregnancy complications | ||||||
| Hypertensive pregnancy disorders | 43 | 4.7% | 17 | 3.3% | 26 | 4.2% |
| HELLP syndrome | 19 | 1.7% | 6 | 1.1 | 13 | 2.1 |
| Suspicious fetal heart rate pattern | 58 | 5.0% | 21 | 4.0% | 37 | 5.9% |
| Premature rupture of membranes | 115 | 10.0% | 50 | 9.6% | 65 | 10.4% |
| Premature labor with need of therapy | 63 | 5.5% | 20 | 3.8% | 43 | 6.9% |
| Gestational cholestasis | 24 | 2.1% | 5 | 1.0% | 19 | 3.0% |
Data are presented for a sample of n=1149 patients.
HELLP, hemolysis, elevated liver enzymes, low platelet count; SD, standard deviation.
Iannaccone. Preterm birth risk after symptomatic SARS-CoV-2 in pregnancy. Am J Obstet Gynecol 2023.
a
Data available for 1034 pregnant women, 3 vaccinations after infection
b
A total of 126 (62.7%) patients were iatrogenic. In 35 cases (17.4 %), COVID-19 was the reason for delivery. In 91 (45.3%) cases, delivery was for obstetrical reasons.