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. 2022 Nov 29;9:732. doi: 10.1038/s41597-022-01845-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Molecular characteristics of HCC cell lines relative to tumour and NAT. (a) Venn diagram shows number of protein groups identified only in cell lines (orange), only in tissue (blue) and both in cell lines and tissue (black). (b) Go enrichment of proteins identified only in cell lines (orange), or only in tissue (blue). (c) The consistency between log2 transformed fold change between tumour tissue versus NAT and cell lines versus NAT. (d) Heatmap shows the normalized abundance of proteins in representative cancer-related pathways. (e) The protein abundance of drug targets expressed in both tissue and HCC cell lines.