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. 2022 Nov 16;13:1005321. doi: 10.3389/fimmu.2022.1005321

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Copyright © 2022 Chen, Zhang, Li, Wu, Zhang and Gong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A low dose of RBD-mFc induced a lasting and strong immune response.BALB/c mice (n=4) were intranasally immunized with different doses of RBD-mFc. Serum was collected and pooled every two weeks after the prime immunization. RBD-specific IgG (A) and IgA (B) were assessed by ELISA. Increasing antibody responses were induced by increasing the immune cycle in a dose-dependent manner. To test for antibody persistence after immunization, a group of 10 μg immunized mice was chosen to assess RBD-specific IgG (C) and IgA (D) duration. Antibodies in serum underwent dynamic change and plateaued until the end of detection.