REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Western Blotting: Anti Mre11	Cell Signaling	Cat# 4895; RRID: AB_2145100
Western Blotting: Anti BRCA1	Cell Signaling	Cat# 9025S; RRID: AB_2734746
Western Blotting: Anti Rad51	Santa Cruz	Cat# sc-7410; RRID: AB_2177093
Western Blotting: Anti Chk1	Santa Cruz	Cat# sc-7898; RRID: AB_2229488
Western Blotting: Anti Per2	Santa Cruz	Cat# sc-25363; RRID: AB_2161685
Western Blotting: Anti total-ß-catenin	Cell Signaling	Cat# 8480; RRID: AB_11127855
Western Blotting: Anti active-ß-catenin	Cell Signaling	Cat# 8814; RRID: AB_2798251
Western Blotting: Anti β-Actin	Sigma-Aldrich	Cat# A5441; RRID: AB_476744
Western Blotting: Anti p-GSK3ß (Ser9)	Cell Signaling	Cat# 5558T; RRID: AB_2798445
Western Blotting: Anti GSK3β	Cell Signaling	Cat#9315S; RRID: AB_490890
Immunoprecipitation: Anti Per2	BD	Cat# 611138; AB_398449
Immunoprecipitation: Anti p-GSK3ß	Santa Cruz	Cat# 5558T; RRID: AB_2798445
Immunoprecipitation:l anti-V5	Proteintech	Cat# 66007-1; RRID: AB_2734694
Chemicals, peptides, and recombinant proteins
RIPA Buffer (10X)	Cell Signaling	Cat# 9806S;
ECL Western blotting detection kit	Biosciences	Cat# R1100;
Fetal Bovine Serum	Corning CellGro	Cat# 35010CV
Penicillin/Streptomycin	Corning CellGro	Cat# 30-002-CI
Eagle’s MEM	Corning CellGro	Cat# 10-010-CV
High-Glucose DMEM	Corning CellGro	Cat# 15-017-CV
L-glutamine	Sigma-Aldrich	Cat# G7513
Cholera Toxin	VWR	Cat# 80055-160
Hydrocortisone	VWR	Cat# AAA16292-03
Insulin	Sigma-Aldrich	Cat# I9278
TRIzol Reagent	Invitrogen	Cat# 15596-018
Lithium Chloride	VWR	Cat# A10531-22
Melatonin	Sigma-Aldrich	Cat# M5250-1G
Dimethyl Sulfoxide(DMSO)	Sigma-Aldrich	Cat# D2650
Annexin-binding Buffer	BioSource, Invitrogen	Cat# V13246
Propidium Iodide	Sigma-Aldrich	Cat# P4864
Triton X-100	Sigma-Aldrich	Cat# X100-500ML
Bovine Serum Albumin (BSA)	Sigma-Aldrich	Cat# 9048-46-8
HEPES	Alfa Aesar	Cat# A1477718
Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF)	R&D Systems	Cat# 415-ML
Hank’s Balanced Salt Solution	Gibco	Cat# 14175-095
MTT Reagent	Sigma-Aldrich	Cat# M-2128
Digitonin	Biosynth	Cat# D3200
Succinate	Alfa Aesar	Cat# AA33386-30
Luciferase Assay Reagent	Promega	Cat# E1483
EDTA	Corning CellGro	Cat# 46034CI
DTT	BIO RAD	Cat# 161-0611
Phenylmethylsulfonyl Fluoride (PMSF)	Sigma-Aldrich	Cat# P7626
Lipofectamine RNAiMAX Reagent	Invitrogen	Cat# 13778-100
propidium iodide	Invitrogen	Cat# P1304MP
Trichloroacetic Acid (TCA)	VWR	Cat# VW3928-2
Turbo Reagent Transfection	Thermo Scientific	Cat# R0531
Critical commercial assays
KAPA Library Quantification Kit	Kapa Biosystems, Inc.	Cat# kk4824
Luciferase-based ATP Assay Kit	AAT Bioquest	Cat# 21617
BCA Protein Assay Kit	Pierce	Cat# 23228
Silencer siRNA Construction Kit	Ambion	Cat# AM1620
TruSeq SBS Kit v3-HS	illumina	Cat # FC-401-3001
PLX304V5	Addgene	Cat# 25890
Software and algorithms
HiSeq Control Software with Real Time Analysis (HCS 1.5/RTA 1.13)		https://www.veritone.com/applications/attribute/?creative=479240006156&keyword=%2Breal-time%20%2Banalysis&matchtype=b&network=g&device=c&utm_medium=cpc&utm_campaign=Attribute&utm_source=google&utm_content=479240006156&utm_term=%2Breal-time%20%2Banalysis&gclid=EAIaIQobChMIq_7k0_fe8gIVvyCtBh3v3QIHEAAYASAAEgL28vD_BwE
CASAVA 1.8 software	Illumina
ImageJ		https://imagej.nih.gov/ij/
TopHat software		https://www.rfpio.com/rfp-software/?utm_source=adwords&utm_medium=cpc&utm_campaign=Search-Demo&gclid=EAIaIQobChMI252hsPfe8gIVyB6tBh2PHg3PEAAYASAAEgKBcvD_BwE
Cufflinks software		http://cole-trapnell-lab.github.io/cufflinks/install/
Flowjo	Tree Star, Inc.	https://pubmed.ncbi.nlm.nih.gov/31249491
GraphPadPrism	GraphPad Software, Inc.	https://www.graphpad.com/scientific-software/prism/
CASPlab		https://casplab.com/
Predictome database
Database for Annotation, Visualization and Integrated Discovery (DAVID) Bioinformatics Resources 6.7		https://david.ncifcrf.gov/summary.jsp
Illumina HiSeq 2000 sequencing system	QB3 Vincent J. Coates Genomics Sequencing Laboratory, UC Berkeley	https://www.illumina.com/documents/products/datasheets/datasheet_hiseq2000.pdf
GEPIA database		http://gepia.cancer-pku.cn/
Recombinant DNA
Human Per2 cDNA vector pLenti6.3/V5-DEST	The University of Texas MD Anderson Cancer Center	https://www.addgene.org/vector-database/6089/
Experimental models: Organisms/strains
C57BL/6 Per2-def	Baylor College of Medicine	Baylor College of Medicine
Per2 associated DNA repair genes	NCBI Gene Expression Omnibus (GEO)	GSE128418
RNA-Seq data of Per2Def versus Per2wt mouse cells	NCBI Gene Expression Omnibus (GEO); Li Lab	GSE128418 This paper
Per2-associated mitochondrial function genes	NCBI Gene Expression Omnibus (GEO)	GSE128418
Per2-Wt cell lines	Li Lab	This paper
Per2-Def cell lines	Li Lab	This paper
Per2 siRNA sequence set	Li Lab	This paper
Other
Zeiss LSM710 confocal microscope system	ZEISS	https://www.zeiss.com/corporate/int/home.html
Turner TD20/20 Luminometer	Promega	https://www.promega.com/products/microplate-readers-fluorometers-luminometers/microplate-readers/glomax-discover-system/?catNum=GM3000&gclid=EAIaIQobChMI7afn0vbe8gIV-BitBh3CQQchEAAYAiAAEgJTAvD_BwE