Table 2.

Comparison of the scores of cognitive function test before and after the social distancing due to COVID-19 pandemic

Cognitive variable			Date of first diagnosed with AD dementia		Total (N=130)
			2019.1–2019.10 (N=72)	2019.11–2021.3 (N=58)
MMSE
	Baseline
		Mean±SD	22.83±3.77	21.64±4.27	22.30±4.03
		Between p-value	0.126
	1 year
		Mean±SD	21.67±3.63	20.34±4.44	21.08±4.05
		Between p-value	0.123
	Difference
		Mean±SD	-1.17±3.10	-1.29±2.60	-1.22±2.88
		Within p-value	<0.001	<0.001	<0.001
		Between p-value	0.889
CDR
	Baseline
		Mean±SD	1.04±0.48	0.97±0.47	1.01±0.48
		Between p-value	0.346
	1 year
		Mean±SD	1.10±0.44	1.34±0.52	1.20±0.49
		Between p-value	<0.004
	Difference
		Mean±SD	0.06±0.47	0.36±0.46	0.19±0.49
		Within p-value	0.466	<0.001	<0.001
		Between p-value	<0.001
CDR-SB
	Baseline
		Mean±SD	4.36±2.29	4.51±2.89	4.43±2.57
		Between p-value	0.987
	1 year
		Mean±SD	6.06±2.69	7.51±3.37	6.70±3.09
		Between p-value	0.011
	Difference
		Mean±SD	1.69±2.22	3.00±2.15	2.28±2.27
		Within p-value	<0.001	<0.001	<0.001
		Between p-value	<0.001

MMSE, Mini-Mental State Examination; SD, standard deviation; CDR, Clinical Dementia Rating; CDR-SB, Sum of Box for CDR; AD, Alzheimer’s disease