TABLE 7.
Genotype distribution in professional soccer players with matches and training injuries for muscle injuries polygenic profile.
| Symbol | Gene | Polymorphism | dbSNP | Genotype score (Varillas Delgado et al., 2020b) | Training injured professional soccer players | Match injured professional soccer players | p-value |
|---|---|---|---|---|---|---|---|
| ACE | Angiotensin-converting enzyme | I/D | rs4646994 | 2 = DD | 21 (35.0%) | 20 (32.8%) | 0.959 |
| 1 = ID | 29 (48.3%) | 31 (50.8%) | |||||
| 0 = II | 10 (16.7%) | 10 (16.4%) | |||||
| ACTN3 | alpha-actinin-3 | c.1747C>T | rs1815739 | 2 = CC | 16 (26.7%) | 23 (37.7%) | 0.291 |
| 1 = CT | 36 (60.0%) | 28 (45.9%) | |||||
| 0 = TT | 8 (13.3%) | 10 (16.4%) | |||||
| AMPD1 | Adenosine monophosphate deaminase 1 | c.34C>T | rs17602729 | 2 = CC | 25 (41.7%) | 25 (41.0%) | 0.119 |
| 1 = CT | 18 (30.0%) | 27 (44.3%) | |||||
| 0 = TT | 17 (28.3%) | 9 (14.8%) | |||||
| CKM | Muscle-specific creatine kinase | c.*800A>G | rs8111989 | 2 = GG | 9 (15.0%) ↑ | 3 (4.9%) ↓ | 0.178 |
| 1 = GA | 19 (31.7%) | 21 (34.4%) | |||||
| 0 = AA | 32 (53.3%) | 37 (60.7%) | |||||
| MLCK | Myosin Light Chain Kinase | c.37885C>A | rs28497577 | 2 = AA | 0 (0.0%) | 0 (0.0%) | 0.009 |
| 1 = CA | 7 (11.7%) ↓ | 19 (31.1%) ↑ | |||||
| 0 = CC | 53 (88.3%) ↑ | 42 (68.9%) ↓ | |||||
| Myosin Light Chain Kinase | c.49T>C | rs2700352 | 2 = CC | 38 (63.3%) | 39 (63.9%) | 0.916 | |
| 1 = CT | 19 (31.7%) | 18 (29.5%) | |||||
| 0 = TT | 3 (5.0%) | 4 (6.6%) |