Figure 2.
Hepatocyte-specific restoration of Gdf15 expression reduces body weight and reverses hyperinsulinemia in Gdf15 knockout-first mice
(A) Body weight after LFD (WT; 10% kcal fat) and HFD (WT, KO + GFP, KO + FLP; 60% kcal fat) feeding.
(B and C) Fat and lean mass measured by 1H-NMR.
(D) Liver triglyceride levels expressed as mg per g liver.
(E–G) Plasma levels of triglycerides (E), nonesterified fatty acids (NEFA; F) and insulin (G). Data are the mean ± SEM for n = 6–9/group. Data analyzed by 1-way ANOVA with multiple comparison testing. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001.