Table 3.

Change in duodenal polyp number from baseline

				Change (month 6–baseline), Mean (SD)
	No. of participants	Baseline, mean (±SD)	Month 6, mean (±SD)	Absolute change mean (±SD)	% change mean (±SD)	% change (95% CI)	P value
Number of duodenal polyps
All evaluable participants	42	44.6 (36.97)	31.7 (30.24)	−12.8 (22.96)	−10.7 (16.82)	−15.9 to −5.4	0.0002*
Severity of duodenal polyposis
Spigelman 3	32	49.8 (39.59)	36.3 (32.82)	−13.5 (24.30)	−9.7 (13.07)	−14.4 to −5.0	0.0002*
Spigelman 2	10	27.8 (20.41)	17.2 (12.14)	−10.6 (18.99)	−13.7 (26.21)	−32.5 to 5.0	0.1322*
APC genetic mutation
Yes	36	46.1 (38.36)	32.1 (31.31)	−14.0 (24.25)	−11.9 (15.86)	−17.3 to −6.6	<0.0001*
No	6	35.3 (28.05)	29.7 (25.09)	−5.7 (11.67)	−3.2 (21.89)	−26.1 to 19.8	0.7388*
Rash acneiform/maculopapular
Yes	23	45.5 (45.18)	29.5 (32.74)	−16.0 (26.96)	−10.4 (15.90)	−17.3 to −3.6	0.0047*
No	19	43.5 (24.81)	34.4 (27.55)	−9.1 (16.89)	−11.0 (18.31)	−19.8 to −2.2	0.0108†
Sex
Female	19	40.2 (23.85)	32.1 (23.42)	−8.1 (11.20)	−7.1 (10.72)	−12.3 to −1.9	0.0097*
Male	23	48.2 (45.28)	31.4 (35.43)	−16.8 (29.05)	−13.6 (20.32)	−22.4 to −4.8	0.0039*
Median age
≤42	21	44.2 (29.60)	32.8 (32.04)	−11.5 (18.71)	−11.9 (18.60)	−20.4 to −3.5	0.0081*
>42	21	44.9 (43.87)	30.7 (29.08)	−14.2 (26.96)	−9.4 (15.19)	−16.4 to −2.5	0.0099*

*Paired t-test of observed mean change, %, against 0%.

†Paired signed-rank test of observed median change, %, against 0%.

APC, aerobic plate count; FAP, familial adenomatous polyposis.