Fig. 3.

The impact of dietary intervention on the colon transcriptome. A Volcano plots showing the expression of significantly downregulated (blue) and upregulated (red) genes in the FCD and NCD groups. Blue and red dots represent significant DEGs, with the lines denoting a cutoff P value of <0.05. B Heatmap showing the expression of genes involved in the colons of mice subjected to dietary intervention. The red square indicates upregulated genes, and the blue square indicates downregulated genes. For RNA-sequencing data, n = 4 per group. Key genes are highlighted in red. C Gene Ontology (GO) enrichment analysis among the significantly regulated transcripts from the colons of the FCD and NCD groups