Fig. 3. Effect of elacestrant versus fulvestrant on ER-mediated transcription and translation.

A Log2 expression of E-regulated genes together with ESR1 in MCF7 and both MCF7-LTED cell lines after treatment with 10 nM fulvestrant or 100 nM elacestrant. All treatments were performed in the presence of 1 nM E2. B Heatmap displaying changes in hallmark pathways following treatment with 10 nM fulvestrant (FULV) or 100 nM elacestrant (EL) in MCF7, MCF7-LTED^wt and MCF7-LTED^Y537C. C Effect of 100 nM elacestrant and 10 nM fulvestrant upon protein abundance of cell cycle markers and E-regulated proteins in MCF7, MCF7-LTED^wt and MCF7-LTED^Y537C. (Data from n = 5 biological experiments, per treatment per cell line).