Table 12.
Other different types of antibacterial hydrogels.
| Material(s) | Antibacterial agent(s) | Major finding(s) | Year, ref |
|---|---|---|---|
| OHA-AT/CEC | Amoxicillin | Excellent anti-oxidant Cell compatibility on C2C12 cells Antibacterial properties against E. coli and S. aureus Accelerated wound healing |
2019 [289] |
| Poly (ionic liquid)/PVA | Poly (ionic liquid) | High mechanical strength Antibacterial activity can kill S. aureus, E. coli, and B. subtilis Biocompatibility on MC3T3-E1 cells Promotes wound healing |
2019 [290] |
| QCS-MPAM | QCS | Excellent mechanical strength Biocompatibility on L929 Antibacterial effect against E. coli, S. epidermidis, and S. aureus Promotes wound healing |
2019 [291] |
| Gel-MA/BACA/Cu | Cu NPs | No cytotoxicity for NIH-3T3 fibroblast Antibacterial properties against E. coli and S. aureus Promotes tissue regeneration |
2019 [13] |
| Hydrogel-based PVP/PVA/PN | PN | Highest swelling rate High antibacterial ability against E. coli and S. aureus |
2019 [292] |
| Hydrogels incorporating CHG | CHG | Antibacterial properties against E. coli and S. aureus Non-toxic Promotes wound healing |
2020 [293] |
| Hydrogels loaded with heparinized ZnO NPs | ZnO NPs | Biocompatibility on L-929 and HDF cells Antibacterial effect against E. coli and S. aureus Enhanced re-epithelialization and collagen formation in vivo |
2020 [294] |
| Hydrogel based on chitosan/hyaluronan/PCDQ | PCDQ | Antibacterial properties against E. coli, K. pneumoniae, P. aeruginosa, S. aureus, and S. haemolyticus Non-toxic on fibroblast cells (NIH 3T3) Enhanced re-epithelialization |
2021 [295] |
| Hydrogel-based ADH/γ-PGA/(KGM) | γ-PGA/OKGM | Antibacterial ability against E. coli and S. aureus Promote inflammatory response in rats Enhance wound healing |
2021 [296] |
| polyethylene glycol monomethyl ether Modified glycidyl methacrylate functionalized chitosan (CSG-PEG), methacrylamide dopamine (DMA) and zinc | zinc | Have excellent inherent antibacterial activity against Methicillin-resistant S. aureus (MRSA) Promote the expression of CD68 and CD31 Enhance wound infection healing in vivo |
2022 [297] |
| Oxidized alginate (ADA) and catechol-modified gelatin (Gel-Cat) polydopamine decorated silver nanoparticles (PDA@AgNPs) | (PDA@AgNPs) | Have antibacterial properties against S. aureus and E. coli in vitro Reduce wound infection in vivo Enhance angiogenesis |
2022 [298] |
| Gelatin/iron- based metal-organic framework nanocomposite/Camellia sinensis (CS) | (CS) | Water absorption was increased due to the interaction of iron-based metal-organic framework within the hydrogel matrix Show antibacterial property against “Bacillus serous”, “S. aureus”, “S. mutans"," E. coli”, “Klebsiella pneumoniae”, and “P. aeruginosa" |
2022 [299] |
| 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-doped multifunctional/quaternized carboxymethyl chitosan (QCMCS) and oxidized hyaluronate (HA-CHO) | Quaternary ammonium | Have a rheological property Exhibit inherent antibacterial and antioxidant properties Have excellent cytocompatibility Reduce the level of hemolysis |
2022 [300] |
| polyethyleneimine (PEI), polyethylene glycol (PEG), hexachlorocyclic triphosphonitrile (HCCP), and gold nanoparticles | gold nanoparticles | Antibacterial effect against MRSA and S. aureus Show antioxidative activity |
2022 [301] |
Abbreviations: (ADA) Oxidized alginate; (ADH) adipic acid dihydrazide; (CS) Camellia sinensis; (CSG-PEG); polyethylene glycol monomethyl ether modified glycidyl methacrylate functionalized chitosan; (CHG) Chlorhexidine gluconate; (DMA) methacrylamide dopamine; (Gel-Cat) catechol-modified gelatin; (HA-CHO) oxidized hyaluronate; (HCCP) hexachlorocyclic triphosphonitrile; (Gel-MA/BACA/Cu) Methacrylate modified gelatin and N, N-bis(acryloyl)cystamine-chelated Cu nanoparticles; (KGM) Konjac glucomannan; (OKGM) oxidized Konjac glucomannan; (PN) Pomegranate; (PCDQ) Phosphatidylcholine dihydroquercetin; (PDA@AgNPs); polydopamine decorated silver nanoparticles; (γ-PGA) γ-polyglutamic acid; (PEI) polyethylenimine; (PEG) polyethylene glycol; (QCS-M-PAM) Quaternized chitosan-Matrigel-polyacrylamide; (QCMCS) multifunctional/quaternized carboxymethyl chitosan; (TEMPO) 2,2,6,6-tetramethylpiperidine-1-oxyl-doped.