Table 3.
Radiation/photo-sensitive antibacterial hydrogels as wound dressings.
| Material(s) | Antibacterial agent(s) | Major finding(s) | Year, ref |
|---|---|---|---|
| SA, PEO, Pluronic F127, and lavender oil |
Lavender oil | Nontoxic on HFF-1 cells Proper mechanical properties UVB-triggered hydrogel Antibacterial property against S. aureus Anti-inflammation behavior |
2016 [199] |
| GelMA, MeTro, and antimicrobial peptide Tet213 |
Antimicrobial peptide Tet213 | Antimicrobial activity against Gram (−) and (+) bacteria (MRSA and E. coli) Improve porosity, degradability, swellability, mechanical property, and adhesiveness Sprayable visible-light-responsive crosslinking hybrid hydrogel Biocompatibility, biodegradation, and nontoxic in vivo and in vitro (NIH-3T3 cells and rat subcutaneous skin) |
2017 [200] |
| BTDA, HEMA, PEGD, chitosan, and methylene blue | Chitosan | Post-UV irradiation responsive (660 nm) Antibacterial activity against E. coli and S. aureus in vitro and in vivo |
2018 [201] |
| Rose bengal/polypyrrole hybrid poly(vinyl alcohol) hydrogel and rhEGF | Rose Bengal | Antibacterial activity against E. coli and S. aureus in vitro and in vivo at mild temperatures (45 °C) under dual light irradiation (808 nm NIR light and 550 nm VL irradiation) | 2021 [202] |
| Graphene hybrid supramolecular hydrogel | Photothermally responsive active Graphene | Antibacterial behavior against MRSA Promote granulation-tissue formation by reducing inflammation, enhancing angiogenesis and collagen deposition in an acute wound infection model |
2021 [203] |
| Ag2S quantum dot/mSiO2 NPs and 3-(trimethoxylmethosilyl) propyl methacrylate | Ag+ | NP hydrogel with photothermal and photodynamic characteristics under 808 nm (NIR) light irradiation, with a photothermal conversion efficiency of 57.3% for releasing the Ag+ Antibacterial activity E. coli & MRSA (inhibition rate of 99.7% and 99.8%, respectively) Enhancing collagen coverage area and bacterial clearance in vivo |
2022 [204] |
| Ag nanoparticles/phosphotungstic acid-polydopamine nano-flowers and chitosan (CS)/gelatin (GE) | Ag+ | Anti-bacterial activity against both gram-negative E. coli and gram-positive S. aureus with releasing Ag + under NIR and accelerating wound healing in vivo | 2022 [205] |
Abbreviations: (BTDA) 3,30,4,40-benzophenone tetracarboxylic dianhydride; (GelMA) Gelatin methacryloyl; (HEMA) 2-hydroxyethyl methacrylate; (MeTro) Methacryloyl tropoelastin; (PEGD) Poly ethylene glycol diacrylate; (GT-DA/chitosan/CNT) gelatin-grafted-dopamine and polydopamine-coated carbon nanotubes; (PDA/Cu-CS) polydopamine (PDA) and copper-doped calcium silicate ceramic (Cu-CS).