Table 9.
Different wound dressing hydrogels under clinical trials.
|
Product(s) |
Treatment procedure | Number of patients | Period follow up | Country | Significant finding(s) | Year, ref |
|---|---|---|---|---|---|---|
| SilvaSorb® Gel | Control group treatment with Silvadene® silver sulfadiazine cream, a randomized group with treatment with Silva Sorb Gel | 24 patients | Day 1 and every 2–3 days for up to 21 days | Philadelphia, Pennsylvania (USA) | The SilvaSorb Gel boosts re- epithelialization and reduces pain Reduces infection |
2009 [277] |
| Human fibroblast growth factor 2 FGF-2 (rhFGF-2) in a gelatin hydrogel | Randomly assigned to three groups receiving a single injection of the gelatin hydrogel containing either placebo or 0.8 mg (low-dosage group) or 2.4 mg (high-dosage group) of rhFGF-2 | 194 Patients |
24-week | Institutions in Japan | The percentages of patients with the radiographic bone union were higher in the rhFGF-2-treated groups (p = 0.031 and 0.009 in low- and high-dosage groups, respectively) compared with the placebo group, although there was no significant difference between low- and high-dosage groups. | 2010 [278] |
| Protease-modulating polyacrylate- (PA-) containing hydrogel | Control group treatment with amorphous hydrogel, second group treatment with PA-based hydrogel | 75 patients | Two weeks wound assessment on days 7 and 14 | France | The PA-based hydrogel group showed a considerable reduction in fibrin and necrotic tissue PA-based hydrogel group increases the area covered by granulation tissue |
2014 [279] |
| Punica granatum L. Hydrogel for Wound Care Treatment | 2% (w/w) Punica granatum peel ethanolic extract (PGMF) based on a hydrophilic cream and zinc oxide, Oral iron therapy | A 76-year-old woman | Six weeks | Brazil | The ulcer had decreased to one-quarter of its original size and had healed entirely six weeks later. No adverse effects of PGMF were observed. | 2016 [280] |
| Oleogel-S10 | Control group treatment with Octenilin®, randomized group treatment with Oleogel-S10 | 61 patients | Wound dressings were changed every two days at 12 months | Ten centers in 4 countries (Germany, n = 4; Sweden, n = 2; Switzerland, n = 1; UK, n = 3) | Oleogel-S10 has a higher antibacterial effect against Gram-positives and Gram-negatives; Increased the percentage of epithelialization; Oleogel-S10 reduced the texture, pigmentation, and redness of the skin |
2018 [281] |
| Chitosan Gel | The tolerability and efficacy of chitosan gel formulation were determined | 20 patients | 30 days (Dressing change twice a week) | Italy | Treatment was effective Increase the wound healing rate |
2018 [282] |
Abbreviations: (rhFGF-2) Human fibroblast growth factor 2 FGF-2; (PA) polyacrylate; (PGMF) Punica granatum peel ethanolic extract.