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. 2022 Nov 16;13:975958. doi: 10.3389/fimmu.2022.975958

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Copyright © 2022 Gurram, Wei, Yu, Kamenyeva, Chung, Zheng, Butcher, Kabat, Liu, Khillan and Zhu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GATA3 KO “Th2” cells and “ILC2s” are identifiable in the Gata3 ^ZsG-fl/flCreERT2 mice. Mice were challenged with papain as shown in Figure 3A and injected (i.p.) with tamoxifen on day 14. The mice were euthanized on day 16 to analyze ILC2 and Th2 cell responses. (A) Gata3 ^fl/fl and Gata3 ^fl/fl CreERT2 mice were challenged with papain and injected with tamoxifen followed by flow cytometric analysis of Th2 cells (left panel) and ILC2s (right panel) in lung. (B) Gata3 ^ZsG-fl/fl, and Gata3 ^ZsG-fl/fl CreERT2 mice were challenged with papain and injected with tamoxifen followed by flow cytometric analysis of Th2 cells (left panel) and ILC2s (right panel) in lung. (C) Flow cytometric analysis of IL-5 and IL-13-expressing Th2 cells (left panel) and ILC2s (right panel) among the ZsGreen⁺ cells from the Gata3 ^ZsG-fl/fl and Gata3 ^ZsG-fl/flCreERT2 mice challenged with papain and injected with tamoxifen. Results are representative of two independent experiments.