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. 2022 Nov 7;3(12):100430. doi: 10.1016/j.jtocrr.2022.100430

Figure 2.

Figure 2

PM-specific ERV. (A) Expression of two representative ERV sequences ERVmap_1248 and ERVmap_1064 increases in tumors but not the control ERVmap_k-48. (∗) p less than 0.05; (∗∗) p less than 0.01; (∗∗∗) p less than 0.001; (∗∗∗∗) p less than 0.0001; ns, not significant, Mann-Whitney test. (B) RT-qPCR validation of ERV expression in samples from human nontumor tissue and tumor tissue. (∗) p less than 0.05; (∗∗) p less than 0.01; (∗∗∗) p less than 0.001; ns, not significant, Mann-Whitney test. (C) Location of ERVmaps and other ERVs with enriched expression in PM. The ideogram was created using http://visualization.ritchielab.org/phenograms/plot. ERV, endogenous retrovirus; PM, pleural mesothelioma; RT-qPCR, quantitative reverse-transcriptase polymerase chain reaction.