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Proposed pathways of hnRNP K unfolding i-motif DNA. The resolving processes include well-folded i-motif structures, opposite hairpins, neighboring hairpins, and unfolded ssDNA, corresponding to the FRET values of ∼0.9, ∼0.7, ∼0.6, and ∼0.4, respectively. Their state transitions are indicated by two-way arrows. hnRNP K, heterogeneous nuclear ribonucleoprotein K.
