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. 2022 Nov 2;298(12):102670. doi: 10.1016/j.jbc.2022.102670

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© 2022 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

All three KH domains can unfold i-motif DNA.A, schematic diagram of KH1-3 and Py25′ i-motif DNA. B, single-molecule FRET (smFRET) histograms obtained from adding 1 μM KH1 (top panel), KH2 (middle panel), and KH3 (bottom panel) at series time at pH 5.8. C, multipeak Gaussian distributions were used to fit the smFRET histograms at 10 min, showing four peaks. The peak values are inserted in the corresponding figures. D, resolving fractions of Py25′ i-motif DNA at different times after the addition of 1 μM proteins. Single-exponential decays were used to fit the resolving fractions. The parameters are shown in Table S3.