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. 2022 Nov 16;13:1048758. doi: 10.3389/fimmu.2022.1048758

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Copyright © 2022 Plunkett, Armitage, Inderjeeth, McDonnell, Waithman and Lau

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Development of skin T_RM: Naïve CD8⁺ T cells are activated by dendritic cells in the local draining lymph node. Upon migration to the skin, local environmental factors such as TGF-β induce the transition to a T_RM phenotype. Activation of the transcription factors Blimp-1 and Hobit drives the expression of CD69 which in turn causes the down regulation of S1PR1. In addition, TGF-β stimulates the upregulation of CD103 which binds to E-cadherin in the epidermis to retain cells in tissue. Created with Biorender.com.