Figure 2.
Classical phenotype of skin TRM. Skin TRM up regulate markers of memory such as CD44, CD69 and CD103 while down-regulating the lymphoid homing molecule CCR7 and egress receptors CD62L, S1PR1 and S1PR5. Skin TRM also express a range of inhibitory receptors including PD-1, CTLA-4 and LAG-3. These cells also exhibit a unique transcription factor profile exhibited by increased Blimp-1, Hobit, Runx, AhR and Notch expression with inhibition of Eomes, Tcf-1, T-bet and Klf2. They also show a conventional CD8+ T cell cytolytic profile including Granzyme B, Perforin, TNF-α and IFN-γ expression. Created with Biorender.com.