Table 1.
mCycle wish-list for auto-planning of cervical cancer (50 Gy in 25 fractions).
| Clinical Constraints | ||||
| Structure |
Cost Function
(parameter) |
Shrink margin (cm) | Limit | |
| PTV | Quadratic Overdose (52 Gy) | / | <0.02 Gy | |
| Bowel bag | Overdose DVH (45 Gy) | / | <195.0 cm3 | |
| External | Maximum Dose | / | 53.4 Gy | |
| Planning Constraints | ||||
| Structure |
Cost Function
(parameter values) |
Shrink margin (cm) | Limit | |
| External | Quadratic Overdose (50 Gy) | 0.0 | <0.1 Gy | |
| External | Quadratic Overdose (45 Gy) | 0.3 | <0.2 Gy | |
| External | Quadratic Overdose (40 Gy) | 0.6 | <0.2 Gy | |
| External | Quadratic Overdose (35 Gy) | 0.9 | <0.2 Gy | |
| External | Quadratic Overdose (25 Gy) | 2.5 | <0.3 Gy | |
| Objectives | ||||
| Priority | Structure |
Cost Function
(parameter values) |
Shrink margin (cm) | Goal value (sufficient) |
| 1 | PTV | Target EUD (0.5) | 50.0 Gy | |
| 1 | PTV | Target Penalty (99%) | 50.0 Gy | |
| 2 | Rectum | Parallel (40 Gy, k = 3) | 0.3 | <30.0% |
| 2 | Bladder | Parallel (40 Gy, k = 3) | 0.3 | <33.5% |
| 3 | Rectum | Serial (k = 15) | <46.0 Gy | |
| 3 | Bowel bag | Parallel (40 Gy, k = 3) | 0.3 | <20.0% |
| 3 | Bowel bag | Serial (k = 15) | <43.0 Gy | |
| 3 | Bladder | Serial (k = 15) | <47.0 Gy | |
| 4 | Bowel bag | Overdose DVH (45 Gy) | <14.0% (7.0%) | |
| 4 | Right femoral head | Serial (k = 15) | <38.0 Gy | |
| 4 | Left femoral head | Serial (k = 15) | <38.0 Gy | |
| 5 | External | Conformality | <0.75 | |
| 6 | Right femoral head | Serial (k = 1) | <30.0 Gy | |
| 6 | Left femoral head | Serial (k = 1) | <30.0 Gy | |
| 7 | Rectum | Serial (k = 1) | <30.0 Gy | |
| 8 | Bladder | Serial (k = 1) | <35.0 Gy | |
Priority: order list according to which the objectives (cost functions) are optimized. Shrink margin: creates a buffer zone between the PTV and overlapping structures to avoid conflict between the applied cost functions of each of the structures. PTV, planning target volume; DVH, dose volume histogram; EUD, equivalent uniform dose.