TABLE 4.
Antiproliferative activities of compounds 3a-3v against ESCC cell lines (n = 5).
| Nr | IC50 (μM) 48 h | Nr | IC50 (μM) 48 h | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SHEE | KYSE70 | KYSE410 | KYSE450 | SHEE | KYSE70 | KYSE410 | KYSE450 | ||
| 3a | 12.14 ± 0.97 | 10.22 ± 0.88 | 48.57 ± 2.16 | 7.24 ± 0.65 | 3l | 4.82 ± 0.23 | 4.25 ± 0.21 (5.13 ± 0.23) | 5.94 ± 0.41 (5.30 ± 0.28) | 3.40 ± 0.16 (8.59 ± 0.78) |
| 3b | 6.03 ± 0.48 | 8.85 ± 0.67 | 10.67 ± 0.86 | 11.60 ± 1.02 | 3m | >50 | >50 | >50 | >50 |
| 3c | 6.23 ± 0.37 | 5.84 ± 0.36 | >50 | 13.81 ± 1.13 | 3n | 8.05 ± 0.71 | 6.87 ± 0.51 | 8.23 ± 0.92 | 13.37 ± 0.99 |
| 3d | 7.20 ± 0.71 | 7.35 ± 0.70 | 8.67 ± 0.71 | 13.47 ± 1.21 | 3o | 22.35 ± 1.26 | 14.60 ± 0.96 | >50 | 4.81 ± 0.36 |
| 3e | 10.33 ± 0.84 | 7.75 ± 0.68 | 11.68 ± 1.01 | 21.84 ± 1.47 | 3p | >50 | 19.92 ± 1.31 | >50 | >50 |
| 3f | >50 | 25.04 ± 1.53 | >50 | 45.03 ± 2.53 | 3q | >50 | 20.71 ± 1.73 | >50 | 21.80 ± 1.12 |
| 3g | 8.01 ± 0.77 | 6.13 ± 0.31 | 10.88 ± 0.99 | 4.51 ± 0.29 | 3r | 20.99 ± 1.11 | 7.32 ± 0.62 | 9.23 ± 0.97 | 28.11 ± 1.18 |
| 3h | 22.59 ± 1.19 | 18.43 ± 1.05 | >50 | 16.70 ± 1.31 | 3s | 14.17 ± 0.94 | 9.35 ± 0.89 | 19.22 ± 1.22 | 23.35 ± 1.13 |
| 3i | 28.08 ± 1.38 | 7.02 ± 0.64 | >50 | 10.02 ± 0.93 | 3t | 33.26 ± 1.99 | >50 | >50 | 45.62 ± 2.01 |
| 3j | >50 | 50 | >50 | 12.52 ± 1.22 | 3u | >50 | >50 | >50 | >50 |
| 3k | 12.52 ± 1.03 | 5.05 ± 0.34 | 21.87 ± 1.39 | 6.25 ± 0.57 | 3v | 8.26 ± 0.71 | 6.93 ± 0.37 | 21.55 ± 1.35 | 11.04 ± 0.97 |
| icotinib | 19.16 ± 1.29 | >50 | >50 | 30.4 ± 1.96 | — | — | — | — | — |
| — | — | (>50) | (>50) | (>50) | — | — | — | — | — |
Conditions: The absorbance at 490 nm of MTT, were measured using a microplate reader (Thermo). Data are shown as mean ± SD.