TABLE 2.

Comparison of available αS fibril structures and an overview of K58-E61 salt bridge.

		Orientation
N-terminal-αS	Salt bridge K58-E61	K58	E61	PDB ID	Method	References
Full-length
NH2-αS, 1–140	Broken	Out	In	2N0A	ssNMR	Tuttle et al., 2016
N-α-acetyl-αS, 1–140	Present	In	In	6A6B	cryoEM	Li Y. et al., 2018
N-α-acetyl-αS, 1–140	Present	In	In	6OSJ	cryoEM	Ni et al., 2019
NH2-αS, 1–140	Broken	Out	In	6FLT	cryoEM	Guerrero-Ferreira et al., 2018
Polymorph
NH2-αS rod	Broken	Out	In	6CU7	cryoEM	Li B. et al., 2018
NH2-αS twister	Broken	Out	In	6CU8	cryoEM	Li B. et al., 2018
NH2-αS fibril polymorph 2A	Broken	Out	Out	6SSX	cryoEM	Guerrero-Ferreira et al., 2019
NH2-αS fibril polymorph 2B	Broken	Out	Out	6SST	cryoEM	Guerrero-Ferreira et al., 2019
*N-α-acetyl-αS filament: MSA Type I	Broken	Out	In	6XYO	cryoEM	Schweighauser et al., 2020
*N-α-acetyl-αS filament: MSA Type II-1	Broken	Out	In	6XYP	cryoEM	Schweighauser et al., 2020
*N-α-acetyl-αS filament: MSA II-2	Broken	Out	In	6XYQ	cryoEM	Schweighauser et al., 2020
Truncations/Modifications
NH2-αS,1-121	Broken	Out	In	6H6B	cryoEM	Guerrero-Ferreira et al., 2018
N-α-acetyl-αS, 1–103	Present	In	In	6OSM	cryoEM	Ni et al., 2019
N-α-acetyl-αS, 1–122	Broken	Out	In	6OSL	cryoEM	Ni et al., 2019
NH2-αS phosphoTyr39 (twist dimer)	Broken	Out	Out	6L1T	cryoEM	Zhao et al., 2020b
NH2-αS phosphoTyr39 (twist trimer)	Broken	Out	Out	6L1U	cryoEM	Zhao et al., 2020b
PD mutants
NH2-αS E46K, 1–140	Broken	Out	Out	6UFR	cryoEM	Boyer et al., 2020
N-α-acetyl-αS E46K, 1–140	Broken	Out	Out	6L4S	cryoEM	Zhao et al., 2020a
N-α-acetyl-αS A53T, 1–140	Present	In	In	6LRQ	cryoEM	Sun et al., 2020
NH2-αS H50Q Wide Fibril	Present	In	In	6PES	cryoEM	Boyer et al., 2019
NH2-αS H50Q Narrow Fibril	Present	In	In	6PEO	cryoEM	Boyer et al., 2019