Table 1:
Patients characteristics and risk factors
| Risk Factor | Category | ABL-class | ABL1 | ABL2 | CSF1R | PDGFRB | Pearson χ2 |
|---|---|---|---|---|---|---|---|
| N (%) | N | N | N | N | |||
| 122 | 40 | 8 | 10 | 64 | |||
| Sex | Male | 76 (62%) | 25 | 4 | 7 | 40 | |
| Female | 46 (38%) | 15 | 4 | 3 | 24 | 0.86* | |
| Age at diagnosis | mean±sd (years) | 9.7±5.1 | 7.1±5.3 | 14±4.3 | 10.4±4.5 | 10.7±4.5 | |
| 1–9 yr | 54 (44%) | 26 | 1 | 3 | 24 | ||
| 10–18 yr | 68 (56%) | 14 | 7 | 7 | 40 | 0.0066* | |
| WBC at diagnosis | mean±sd (counts ×10e9/L) | 97.9±114.8 | 99.1±110.1 | 142.4±71.1 | 65.5±100.4 | 96.7±124 | |
| <50 | 62 (51%) | 21 | 0 | 7 | 34 | ||
| 50–100 | 18 (15%) | 4 | 2 | 1 | 11 | ||
| ≥100 | 41 (34%) | 14 | 6 | 2 | 19 | 0.079* | |
| NCI risk | SR | 28 (23%) | 14 | 0 | 2 | 12 | |
| HR | 93 (77%) | 25 | 8 | 8 | 52 | 0.081* | |
| CNS involvement | no | 112 (97%) | 38 | 8 | 9 | 57 | |
| yes | 4 (3%) | 0 | 0 | 1 | 3 | 0.34* | |
| Testis involvement | no | 44 (100%) | 15 | 3 | 4 | 22 | |
| yes | 0 (0%) | 0 | 0 | 0 | 0 | N/A | |
| Ikaros status | IKZF1 wildtype | 23(39%) | 4 | 2 | 2 | 15 | |
| IKZF1 deleted | 36 (61%) | 12 | 2 | 5 | 17 | 0.44* | |
| of which only IKZF1 deleted | 13 (22%) | 5 | 0 | 2 | 6 | ||
| or IKZF1 and PAX5 and/or CDKN2A/2B deleted | 23 (39%) | 7 | 2 | 3 | 11 | 0.72** | |
Percentage of cases per category out of total number of cases with registered information is given in parentheses.
*
Pearson χ2 p-values are estimates because the number of cases is less than 5 for some variables.
**
IKZF1 “plus” versus IKZF1 only.
N/A, Pearson χ2 not applicable since no patients with testis involvement were reported. Number of patients with missing data: WBC 1; NCI risk 1; CNS involvement 6; testis involvement 32.