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. 2022 Nov 16;13:1047909. doi: 10.3389/fphys.2022.1047909

FIGURE 4.

FIGURE 4

SkQ1 protects the ultrastructure of myocardial mitochondria and attenuates mtDNA release after HS. (A) Representative TEM images of mitochondria of the rat myocardial tissues from the HS + vehicle and HS + SkQ1 group rats. (B–G) Statistical results of the myocardial mitochondrial volume density, length, width, perimeter, area, and circularity index in the HS + vehicle and HS + SkQ1 group, n = 200 mitochondria from 5 rats per group, ***p < 0.001 compared with the HS + vehicle group. (H) Representative TEM images of myocardial mitochondrial cristae ultrastructure of the HS + vehicle and HS + SkQ1 group. (I–K) Statistical results of the mitochondrial cristae area, cristae volume, and cristae score, n = 188–200 mitochondria from 5 rats per group, ***p < 0.001 compared with the HS + vehicle group. (L) Statistical results of the mitochondrial DNA CytB content in peripheral blood of the HS + vehicle and HS + SkQ1 group. n = 5 rats per group, *p < 0.05 compared with the sham group.