Table 3.
Logistic regression model of factors associated with persistent culture-positive at 2 months of treatment in patients with PTB (N=73).
| Variable | Univariate | Multivariate, backward elimination | ||
|---|---|---|---|---|
| Crude OR (95% CI) | p value | Adjusted OR (95% CI) | p value | |
| Age (year) | 1.014 (0.982–1.047) | 0.391 | ||
| Male sex | 3.472 (0.700–17.226) | 0.128 | ||
| BMI (kg/m2) | 0.986 (0.815–1.194) | 0.888 | ||
| Smoking status | ||||
| Never smoker | 1 (reference) | |||
| Current smoker | 1.689 (0.417–6.843) | 0.463 | ||
| Ex-smoker | 1.583 (0.269–9.320) | 0.611 | ||
| Blood cell count | ||||
| Platelet count (K/μL) | 1.003 (0.998–1.008) | 0.297 | ||
| Monocyte count (/μL) | 1.001 (0.999–1.003) | 0.465 | ||
| Lymphocyte count (/μL) | 1.000 (0.998–1.001) | 0.664 | ||
| Monocyte-to-lymphocyte ratio | 1.012 (0.996–1.028) | 0.128 | ||
| C-reactive protein (mg/L) (N=68) | 1.108 (0.855–1.435) | 0.439 | ||
| Sputum smear grade | 1.494 (1.004–2.223) | 0.048 | 1.140 (0.668–1.944) | 0.631 |
| INH resistance strain | 1.543 (0.279–8.532) | 0.619 | ||
| Bilateral lung disease | 2.158 (0.614–7.589) | 0.230 | ||
| Radiographic score | 1.521 (1.137–2.035) | 0.005 | 1.427 (1.008–2.021) | 0.045 |
| Nu-cfDNA (104 copies/μL-plasma) | 1.000 (1.000–1.000) | 0.982 | ||
| Mt-cfDNA (106 copies/μL-plasma) | 1.002 (1.000–1.002) | 0.230 | – | |
| Mt-cfDNA > 62.6 x106 copies/μL-plasma a | 10.645 (1.293–87.607) | 0.028 | 9.691 (1.046–89.813) | 0.046 |
a
Optimal cut-off value determined using receiver operating characteristic curve analysis.
BMI, body mass index; Mt-cfDNA, mitochondria cell-free DNA; Nu-cfDNA, nuclear cell-free DNA.