Table 4.
Characteristics of pulmonary tuberculosis (PTB) patients stratified by Mt-cfDNA dynamic change at 2 months of treatment (N=59).
| initially low Mt-cfDNA, decreased at 2 months (n=4) | initially low Mt-cfDNA, increased at 2 months (n=19) | initially high Mt-cfDNA, decreased at 2 months (n=28) | initially high Mt-cfDNA, increased at 2 months (n=8) | P value for trenda | |
|---|---|---|---|---|---|
| Variables | |||||
| Initial Mt-cfDNA (106 copies/μL-plasma) | 33.7 ± 24.7 | 14.6 ± 17.9 | 465.6 ± 451.3 | 129.8 ± 70.7 | 0.023 |
| Change at 2M (106 copies/μL-plasma) | -19.6 ± 20.4 | +75.7 ± 74.3 | -354.1 ± 421.8 | +126.1 ± 132.7 | 0.228 |
| Age (years) | 54.7 ± 24.2 | 59.8 ± 19.7 | 60.1 ± 22.6 | 69.7 ± 18.1 | 0.273 |
| Male sex | 2 (50%) | 12 (63%) | 15 (54%) | 6 (75%) | 0.742 |
| BMI (kg/m2) | 20.0 ± 2.8 | 20.5 ± 2.5 | 21.5 ± 3.5 | 22.8 ± 4.0 | 0.062 |
| Blood cell count | |||||
| Platelet count (K/ul) | 246.8 ± 78.2 | 256.8 ± 84.5 | 267.7 ± 122.2 | 221.2 ± 106.2 | 0.745 |
| Monocyte count (/μL) | 432.7 ± 188.8 | 597.6 ± 341.5 | 597.5 ± 235.1 | 648.8 ± 229.3 | 0.318 |
| Lymphocyte count (/μL) | 1128.7 ± 510.9 | 1189.7 ± 394.0 | 1434.7 ± 530.7 | 1207.7 ± 612.3 (n=41) | 0.363 |
| Monocyte-to-lymphocyte ratio | 0.45 ± 0.32 | 0.53 ± 0.21 | 0.46 ± 0.22 | 0.82 ± 0.81 | 0.174 |
| C-reactive protein (mg/L) (N=55) | 0.59 ± 0.50 | 1.70 ± 2.60 | 1.06 ± 1.47 | 0.47 ± 0.68 | 0.342 |
| In initial culture-positive PTB patients (N=48) | |||||
| Before treatment sputum smear grade | 3 | 0 [0-0.25] | 0 [0-1.5] | 1 [0.5-3] | 0.571 |
| Before treatment smear-positive (n/N) | 1/1 | 4/17 (24%) | 12/25 (48%) | 4/5 (80%) | 0.090 |
| 2-month persistent culture-positive (n/N) | 0/1 | 0/17 | 4/25 (16%) | 2/5 (40%) | 0.023 |
| Bilateral lung disease at baseline | 1 (25%) | 4 (21%) | 11 (39%) | 4 (50%) | 0.168 |
| Radiographic score at baseline | 2 [2–2.75] | 2 [2–4] | 3 [1.25–3.75] | 3 [2–7.25] | 0.182 |
Continuous and categorical data are expressed as mean ± standard deviation (SD) or median with [IQR] and number (%).
BMI, body mass index; Mt-cfDNA, mitochondria cell-free DNA; mo., months.
a
Associations were assessed by Pearson’s correlation test for continuous variables and by χ2 test for linear trends for binary variables.The bold values are the subgroup names according to Mt-cfDNA change at 2 months.