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. 2022 Nov 16;13:1037566. doi: 10.3389/fimmu.2022.1037566

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Copyright © 2022 Park, Lee, Eum, Ko, Min, Yoon, Hwang, Yun, Yang, Shin and Chung

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Study design. Between January 2010 and December 2018, 1,080 patients were included in the study. Based on a TWCV of 30%, the patients were classified into high- or low-IPV groups. The RM and NRM groups were classified based on the CDR 1.05 ng•mg/mL. Finally, the patients were classified into four groups according to their TAC-IPV and RM/NRM status. CDR, concentration-to-dose ratio; HLA, human leukocyte antigen; IPV, intra-patient variability; NRM, non-rapid metabolizer; RM, rapid metabolizer; TAC-C0, tacrolimus trough level; TWCV, time-weighted coefficient variation.