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. 2022 Nov 14;14(6):730–741. doi: 10.4168/aair.2022.14.6.730

Table. Summary characterization of pediatric AR clusters.

Cluster Description No. of sensitized allergens Type 2 inflammation BHR Airway function impairment Nasal symptoms Asthma morbidity
1 (13.3%) NAR dominant cluster with low type 2 inflammation +− + + +
2 (47.3%) Intermediate type 2 inflammation and low BHR ++ ++ + ++ +
3 (27.0%) High type 2 inflammation and intermediate BHR ++ +++ ++ ++ +
4 (12.4%) High type 2 inflammation and BHR ++ +++ +++ + ++ ++

BHR, bronchial hyper-responsiveness; NAR, non-allergic rhinitis.