Table 2. Comparison of various oral food challenge protocols in FPIES.

Author	Country	Setting	Dose interval	Total dose	Post-OFC observation	Comments
Katz et al. (2011)3	Israel	Inpatient (n = 24)	Dose 1–2: 10 min	385 mL (11.55 g) cow’s milk	3 hrs	Median cumulative reactive dose was 385 mL
			Dose 2–3: 20 min
			Dose 3–4: 20 min
			Dose 4–5: 45 min
			Dose 5–6: 45 min
Caubet et al. (2014)15	USA	Inpatient (n = 180)	3 equal doses over 45 min	0.3 g protein/kg with max of 3 g	4–8 hrs	74/180 OFCs positive
						If subject had IgE to food trigger, OFC administered in incrementally increasing doses every 15 min
Vazquez-Ortiz et al. (2017)16	Spain	Inpatient (n = 81)	3 equal doses every 90 min	0.3 g protein/kg	-	36% reacted to 2nd dose
			7 equal doses every 90 min			51% reacted to 3rd dose
Wang et al. (2019)19	USA	Outpatient (n = 169)	Single dose	One third of full serving for age	4 hrs	Full dose titration at home
						17/169 positive OFCs
						13/152 reactions at home during titration to full dose
						Diarrhea and vomiting in 1 patient that required ED evaluation
Infante et al. (2019)55	Spain	Inpatient (n = 75)	Method 1: 4 doses given over 30 min	Doses of Fish:	Method 1:	Method 1: 95% reacted after full dose reached
			Method 2: only doses 2–4 given, 1 dose every 48 hrs	- Dose 1: ⅛	- After dose 4, 2 hrs	- 18.6% mild, 42% moderate, 39.5% severe reactions
				- Dose 2: ¼	Method 2:	Method 2: 81% reacted after receiving ¼ of full serving
				- Dose 3: ½	- After dose 2, 4 hrs	- 69% mild, 18.8% moderate, 2.5% severe reactions
				- Dose 4: Full serving	- After dose 3, 4 hrs

FPIES, food protein-induced enterocolitis syndrome; OFCs, oral food challenges; IgE, immunoglobulin E; ED, emergency department.