Table 5. Dose adjustment rules in the build-up phase.

Time interval since missed injection	Dose adjustment
Up to 7 days*	Continue as scheduled
8–13 days after missed scheduled injection	Repeat previous dose†
14–21 days after missed scheduled injection	Reduce dose 25%†
Over 21 days after missed scheduled injection	Reduce previous dose 50%†

^*If on a weekly build-up, then it would be up to 14 days after administered injection or 7 days after the missed scheduled injection; ^†Then increase dose at each injection visit as directed on the immunotherapy schedule until therapeutic maintenance dose is reached.