Table 1.
Summary of viruses
| Virus | Deletion/Mutation | Foreign gene/promoter insertion | Reference |
|---|---|---|---|
| HSV-1 | |||
| C134 | Deletion in both copies of γ134.5 gene | IRS1 gene under control of an HCMV immediate early promoter | (Cassady, et al., 2017) |
| G207 | Deletion in both copies of γ134.5 gene and disabling lacZ insertion in UL39 | None | (Mineta, et al., 1995) |
| G47Delta | Deletion of the γ134.5 and α47 genes and a disabling lacZ insertion within UL39 | None | (Todo, et al., 2001) |
| HSV1716 | Deletion in both copies of γ134.5 gene | None | (Streby, et al., 2017) |
| M032 | Deletion in both copies of γ134.5 gene | Human IL-12 gene insertion | (Patel, et al., 2016) |
| rQNestin | Deletion in γ134.5 gene and UL39 | ICP-34.5 under control of synthetic nestin promoter | (Chiocca, et al., 2020) |
| T-Vec | Deletions of the ICP34.5 and ICP47 genes | Granulocyte-macrophage colony-stimulating factor, CMV promoter | (Andtbacka, et al., 2015) |
| Adenovirus | |||
| Ad-TD-nsIL12 | Deletions in E1A, E1B, E3gp-19K genes | Non-secretory IL-12 gene under control of E3gp-19K promoter | (Wang, et al., 2017) |
| CRAd-S-pk7 | Deletion of native E1 promoter | E1A expression under control of human survivin; pk7 encoding polylysine | (Ulasov, et al., 2007) |
| DNX-2401 | Deletion of Rb-binding region from E1A | RGD peptide motif insertion | (Fueyo, et al., 2003) |
| DNX-2440 | Deletion of Rb-binding region from E1A | RGD peptide motif insertion; OX40 ligand expression cassette replacing E3 region | (Jiang, et al., 2017) |
| ICOVIR-5 | Deletion of Rb-binding region from E1A | RGD peptide motif insertion; Substitution of the E1A promoter for E2F1-responsive elements | (Majem, et al., 2006) |
| ONYX-015 | E1B gene deletion preventing production of E1B-55kDa protein | none | (Bischoff, et al., 1996) |
| Poliovirus | |||
| PVSRIPO | Native IRES | Native IRES substituted with IRES from human rhinovirus type 2 | (Gromeier, et al., 2000) |
| Reovirus | |||
| Pelareorep | None relative to wild type reovirus Type 3 Dearing strain | None relative to wild type reovirus Type 3 Dearing strain | (Kicielinski, et al., 2014) |
| Measles Virus | |||
| MV-CEA | None relative to Edmonston vaccine strain | Expresses soluble extracellular domain of human CEA | (Peng, et al., 2002) |
| MV-NIS | None relative to Edmonston vaccine strain | Expresses human thyroidal NIS | (Dingli, et al., 2004) |